Ref9C8

Ref9C8

Back To Index Last Article Next Article

Med. Sci Res., 1991’ 19, 827-828

Pharacokinetic studies of silybin-phosphatidylcholine complex (Siliphos) in liver cirrhosis after multiple doses

Rocco Orlando, Annalisa Fragasso, Mario Lampertico1 and Carlo Marena1

Institute of Internal Medicine, University of Padua, Italy, and 1Medical Department, Inverni della Beffa, Milan, Italy

Journal not found on Medline

Introduction: Silybin is the main active component of silymarin, a standardized extract from the seeds of Silybum marianum Gaertn. (Siliphos) is a complex between silybin and soybean phosphatidylcholine, which exerts protective effects against hepatic lesions induced by toxic agents such as alcohol and phalloidin (1,2).

The data obtained in cirrhotic patients after multiple doses of IdB 1016 (Siliphos) did not show significant differences from those reported after a single dose. They clearly show that the drug does not accumulate in cirrhotic patients.

Furthermore the results indicate no significant difference from healthy control subjects.

It is therefore posited that this substance can be safely employed in long-term treatment of chronic liver patients.

1. Ferenci, P., Dragosics, B., Frank, H. et al. 1985. Abstr. J. Hepatol., 1, S229

2. Salmi, H.A. and Sarna, S. 1982, Scand. J. Gastroenterol., 17, 517-521

 

 

 

 


© 2012 Natural Wellness®. All rights reserved.

This website is brought to you byNatural Wellness®,
providing tools and ideas for optimum health.
Contact Us:
Questions? Contact us by phone during our regular business hours, Mon-Fri, 9am to 5pm EST.
800-364-5722 (Toll Free)
845-361-3900 (NY Area)
Risk-Free Guarantee:
You must be 100% satisfied. If not, we'll replace, exchange, or send you a refund or credit your account for unopened merchandise.
 

* This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Natural Wellness has developed certain nutritional supplements to meet the specified needs of our customers. These products are not intended to diagnose, treat, cure, or prevent a disease, but rather are dietary supplements intended solely for nutritional support. These statements have not been evaluated by the Food and Drug Administration. Testimonials reflect the personal experience of each person quoted. Individual results may vary. The information provided on this site is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. Please consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem.