European Journal of Drug Metabolism and PharmacoKinetics, 1992, Vol. 17, No.
Siliphos versus Silybin
Comparative bioavailability of IbD 1016 (Siliphos), a new
flavanolignan complex, in rats
P. Morazzoni1, M.J. Magistretti1, C. GIACHETTI2 and G. ZANOLO2
della Beffa Rasearch and Development Laboratories, Milan, Italy
Marxer" Institute for Biomedical Research, Ivrea, Italy
National Library of Medicine Citation
The results of this study indicate a superior bioavailabilty of
silybin administered orally as IbD 1016 (Siliphos). This was
due mainly to an impressive increase in gastrointestinal absorbtion.
It also clearly confirmed that pure silybin has a very low bioavailability;
indeed, administered by oral route it does not result in detectable
plasma levels of either unmodified or total silybin.