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Biochemical Pharmacology, Vol. 50 No. 8, pp. 1313-1316, 1995

Scavenging Effect of Silipide (Siliphos), a new Silybin-phospholipid Complex, on Ethanol-Derived Free Radicals

A. Comoglio, A. Tomasi*, S. Malandrino**, G. Poli*** and E. Albano****

*Departments of Experimental Medicine and Oncology and Medical Sciences, University of Torino; ***C.N.R. Centre of Immunogenetics and Experimental Oncology, Torino; **Indena S.p.A. Milano and *Institut of General Pathology, University of Modena, Italy

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The results of this study indicate that (Siliphos) effectively scavenges hydroxhethyl radicals. However, this effect is lost when the same amount of pure silybin is administered instead. The ability of Silipide (Siliphos) to scavenge ethanol-derived radicals along with its antioxidant activity suggests that this drug might be potentially useful in counteracting free radical-mediated injuries involved in the development of liver damage caused by alcohol abuse.


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