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Biochemical Pharmacology, Vol. 43, No. 10, pp 2111-2115, (1992)

Lipid Peroxidation and Irreversible Damage in the Rat Hepatocyte Model

Protection by The silybin-phosopholipid Complex IdB 1016

Rita Carini, Adriana Comoglio, Emanuele Albano and Giuseppe Poli*

Department of Experimental Medicine and Oncology, University of Turin, CNR Centre of Immunogenetics and Experimental Oncology, Corso Raffaello 30, Torino, Italy

See National Library of Medicine Citation

Abstract-IdB 1016 (Siliphos) is a new silybin-phospholipid complex which is more bioavailable than the flavonoid silybin itself and displays free radical scavenging and antioxidant properties in liver microsomes. IdB 1016 (Siliphos) at the concentration which completely prevented MDA formation also protected isolated hepatocytes against toxicity. Similar protection was also obtained in hepatocytes prepared in vivo with IdB 1016 (Siliphos) while rat supplementation with pure silybin was totally inefficient. These results indicate IdB 1016 (Siliphos) as being a potentially useful protective agent against free radical-mediated toxic liver injury.

Moreover, it was demonstrated here for the first time that IdB 1016 (Siliphos) can counteract the hepatotoxic effect of several different compounds acting through oxidative mechanisms, indicating the potential usefulness of the compound as a hepatoprotective agent.

 
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