Pharmacological Research, Vol. 25, No. 2, 1992
Effect of the Flavanolignans of Silybum marianum L. on Lipid Peroxidation in Rat Liver Microsomes and Freshly Isolated Hepatocytes
ENRICA BOSISIO, CINZIA BENELLI AND ONDINA PIROLA
Institute of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Italy
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This study examines the effect of several flavonolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.
The study shows the antioxidant activity of the constituents in silymarin, with silybin proving to be the most valuable.