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Pharmacological Research, Vol. 25, No. 2, 1992

Effect of the Flavanolignans of Silybum marianum L. on Lipid Peroxidation in Rat Liver Microsomes and Freshly Isolated Hepatocytes

ENRICA BOSISIO, CINZIA BENELLI AND ONDINA PIROLA

Institute of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Italy

See National Library of Medicine Citation

This study examines the effect of several flavonolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.

The study shows the antioxidant activity of the constituents in silymarin, with silybin proving to be the most valuable.


 


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